As with all licensed veterinary medicines, FRONTLINE PLUS^®, FRONTLINE TRI-ACT^® and FRONTLINE^® SPOT ON have undergone extensive safety evaluation. When used as directed, pets treated with FRONTLINE^® flea and tick treatments do not pose a health risk to children or adults. It is a recommended precaution that children or adults do not pet, play or sleep with treated animals until the application site is dry.