Yes. FRONTLINE PLUS^® for extra-large dogs can be used on dogs over 40 kg – there’s no upper weight limit for this product. To treat dogs over 60 kg with FRONTLINE TRI-ACT^®, use the appropriate combination of two pipette sizes that most closely matches the bodyweight. To treat dogs over 60 kg with FRONTLINE^® SPOT ON, use two large-sized pipettes for dogs from 20 to 40 kg.